SMEDDS are the preconcentrates of microemulsion, which forms microemulsion when come in contact with GI fluid. This microemulsifyng drug delivery system, are clear dispersions allowing wide range of advantages for formulators in designing liquid dosage form for aqueous insoluble drugs. Present review focuses on the properties of SMEDDS before and after their contact with GI fluid. The review contains the selection criteria of excipients, the formulation method of SMEDDS and their in-vitro evaluation. The advantages of SMEDDS are described with references to other dosage forms and normal emulsions.
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